It may also be used to treat other kinds of cancer, as determined by your doctor. We prospectively determined renal function in 10 untreated lung cancer patients with normal baseline renal function, treated with carboplatin 400 mg m2 day 1 and vincristine 2 mg day 1 and 8 every 4 weeks max. This carboplatin price guide is based on using the drugs. Carboplatin dosage calculator carboplatin injection. Carboplatin by injection national library of medicine. It uses creatinine clearance gfr and target area under. This formula can be used to calculate the carboplatin dose accurately in order to obtain a target auc by using only the. Carboplatin is an anticancer medication indicated for the initial treatment of advanced ovarian carcinoma in established combination with other approved chemotherapeutic agents.
Carboplatin injection is also indicated for the palliative treatment of patients with ovarian carcinoma recurrent after prior. Ask your health care professional for ways to lessen these effects, especially if they are severe. Carboplatin interferes with the growth of cancer cells, which eventually are destroyed. Carboplatin injection may be given alone or with other drugs. It didnt hurt much but my arm went very cold and the thought of it was the most unpleasant part. This means that the dose of carboplatin must be adjusted for any impairment in kidney function. New guidelines for carboplatin dosing memorial sloan. Carboplatin carboplatin dose, indications, adverse. Id had plenty of carbo before with no reaction, so believe me when i tell you this was a total surprise. The calvert formula has been extensively used to determine the dose of carboplatin for a fixed auc and glomerular filtration rate gfr. Kinetic egfr kegfr estimate gfr when creatinine is changing acutely either rising or falling pim2 paediatric index of mortality, revised version serious renal dysfunction postpci assess risk of dialysis or severe increase in creatinine after pci crrt dosing calculator calculate desired dose of dialysate in crrt ncdr aki and dialysis risk. Carboplatin auc calculator calvert formula for carboplatin dosing includes multiple clearance analysis multicalc including. Carboplatin auc calculator globalrph multiple clearance analysis.
Single agent therapy for use in the treatment of recurrent ovarian cancer. Carboplatin prices, coupons and patient assistance programs. However, it is very important that you continue to receive the medicine, even if you begin to feel ill. Carboplatin may cause birth defects if either the male or female is using it at the time of conception. This is a health tool that allows you to compute the total carboplatin dose in mg based on the estimated creatinine clearance level from the cockcroft gault equation and on the targeted auc value there are fields that you need to complete for the results to be consistent such as the gender, age, weight and height in either metric or english. Carboplatin side effects, dosage, interactions drugs. Area under the curve chemotherapy dosing is an effective tool to. Dose adjustment of carboplatin in patients on hemodialysis. Carboplatin dose calculator software free download.
Any electronic tool, including those found on, are not substitutes for clinical experience and expertise. Listing a study does not mean it has been evaluated by the u. This calculator uses the following formula for calculation of carboplatin dose. In our phase i study, the carboplatin dose was escalated with the use of aucs of 12, 15, 18, 21, 24, 28, and 32 mgml per minute. After 24 hours, close to 70% of carboplatin is excreted in the urine unchanged. An electronic tool cannot assess the clinical picture and patientspecific factors.
Several payment sources exist for cancer drugs in ontario, depending on the drug, disease indication, and how and where it is delivered. Carboplatin dose should be calculated using the calvert formula. Auc is the target area under the curve concentration versus time. Carboplatin is a powerful drug that is used to treat various types of cancer in dogs. Carboplatin is given by dripping the medicine slowly and directly into a vein intravenous infusion for 15 minutes or longer.
Carboplatinbased chemotherapy remains the mainstay of treatment for many patients with gynecologic malignancies. Carboplatin dose is calculated by knowing the target auc and gfr glomerular filtration rate. The carboplatin auc dose calculation provides a formula for calculating the dose based upon a patients glomerular filtration rate and carboplatin target area. It is commonly used in treating ovarian cancer that is wide spread and also for curing the small cell lung cancer. Carboplatin intravenous advanced patient information. Carboplatin dosage calculator area under the curve carboplatin clearance carboplatin dosage is calculated from sex, age, weight, serum creatinine and auc area under the curve of carboplatin. Carboplatin usually causes nausea and vomiting that sometimes may be severe.
Your doctor will determine the dose of carboplatin for you based on your weight, height, and kidney function. Total carboplatin dose is calculated in mg and not mgm 2. In the past, multiple assays were used to measure serum creatinine, resulting in considerable. Carboplatin carboplatin this product information is intended only for residents of the united states. In umc11, h727 and h835 lung carcinoid cell line, carboplatin also shows the antiproliferative activities 2. Predictbgl dramatically simplifies blood glucose management and insulin dosing with tracking of insulin on board, variable ratiostargets throughout the day, live sharing between school and parents at homework. Carboplatin auc calculator updated version 2017 globalrph.
This calculator estimates gfr from the cockcroftgault equation. Since the growth of normal body cells may also be affected by carboplatin, other effects also will occur. But when hubby and i counted it back, this dose monday was indeed my 8th dose of carboplatin. Carboplatin is one of the most prescribed cytotoxic drug, which is extensively used in the treatment regimens of several malignancies. Gemcitabine and carboplatin renally dosed regimen for. The use of the calvert formula to determine the optimal carboplatin. Inserted iv and began pumping carboplatin into my body. Carboplatin dose calculator carboplatin auc calculator. Carboplatin dose calculation carboplatin doses are commonly calculated using an equation based on the method of calvert et al. Use the advanced version if you wish to manipulate this value. Carboplatin is a drug used for cancer patients while providing chemotherapy. Intraperitoneal therapy for ovarian cancer with carboplatin trial ipocc the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Acute and cumulative effects of carboplatin on renal function. One established combination regimen consists of carboplatin injection and cyclophosphamide.
Carboplatin dose calculator software pharmacy creatinine drug calculator v. Vancomycin singlelevel dose infused early or latethe globalrph vancomycin singlelevel calculator uses the vd recommended in bauers text. Find comprehensive medical reference information including disease symptoms, diagnoses, treatments, and followup. Find patient medical information for carboplatin intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Carboplatin is a member of the alkylating agents drug class and is commonly used for cancer, cervical cancer and ovarian cancer. As carboplatin is preferentially eliminated through the kidney, clearance can be predicted using parameters of the renal function. Carboplatin may be given alone or with other drugs. Plot of measured versus target area under the curve auc. This is an online calculator to find the dosage of carboplatin auc for a patient using the calvert formula. Carboplatin auc dose calculation calvert formula calculator.
It takes under consideration the creatinine clearance and the desired area under curve. The therapeutic efficiency of carboplatin has been found to correlate the area under curve auc. Because renal function may change through a course of chemotherapy, this calculation should be repeated prior to each dose of carboplatin. Food and drug administration approved carboplatin for use treating patients with ovarian and nonsmall cell lung cancer, and oncologists often use carboplatin offlabel for other cancers. Ifosfamide was administered on days 6 to 3 as a 22hour infusion and mesna each dose was 20% of the total doseday of ifosfamide was administered before the start of ifosfamide and every 6 hours after, including 2 doses after the final ifosfamide infusion. Flat dosing of carboplatin is justified in adult patients with normal. Your doctor will determine the dose of carboplatin injection for you based on your weight, height, and kidney function. Carboplatin is a chemotherapy drug used for treatment of many types of cancer. Calverts formula is used to calculate the dose of carboplatin.
Carboplatin is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. Carboplatin dose calculator for android is a medical application helps you calculate the right carboplatin dose. It uses creatinine clearance gfr and target area under curve for the dose estimation. Carboplatin auc dose calci app ranking and store data app annie carboplatin auc dose calculation calvert formula calculator. Height is necessary for weight correction in obese patients. In routine practice, the carboplatin dose is calculated using an estimated creatinine clearance that is derived from formulas that incorporate the patients serum creatinine. Apexbio carboplatinantitumor agent that forms platinum. Predictbgl is a beautiful insulin dose calculator that predicts hypos and blood sugar levels hours ahead.
Carboplatin dosage calculator area under the curve. Calvert formula for carboplatin dosing multiple clearance calculations multicalc including specialized handling of patients less. This application calculate in order of weight, serum creatinine, age, and target auc. In xenograftbearing mice, carboplatin 60 mgkg had a modest antitumor effect and the relative tumor volumes on day 6 were 8. It is recommended that you use some kind of birth control while you are using carboplatin. Carboplatin injection is given by dripping the medicine slowly and directly into a vein intravenous infusion for 15 minutes or longer. Carboplatin dose calculator for android free download. Carboplatin belongs to the group of medicines known as alkylating agents. Carboplatin auc dose calculator helps to analyze the allowed dosage level for chemotherapy. First of all the creatinine clearance is calculated using the modified modified cockcroftgault formula which is given below. The dose of carboplatin will be different for different. It is most commonly used as a treatment method for osteosarcomas, though it can also be used for melanomas and various other types of cancerous growths as well.